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Thing is special, in description logic it corresponds to TOP, so every class should imply Thing. Literally you can say Thing means everything. An instance of Thing is kind of the universal instance, however I never created an instance of Thing before. The initial domain of a property is certainly Thing, so there is no need to remove Thing from the domain unless you restrict the domain to a specific subclass of  Thing.

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Thanks a lot! Another question: If I am going to use ontology to facilitate biology data mining, would it be better to create two ontologies (biology, and data mining) rather than one (universal framework of bioDataMining)? To what extent Instantiating the ontology to instances will benefit my framework? Or can I implement it without much instances (to write my thesis) I know this is a abstract question, still hope I can get some hints.

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ÒÔÏÂÊÇÒýÓÃhunterdongÔÚ2007-8-17 7:01:00µÄ·¢ÑÔ£º Thanks a lot! Another question: If I am going to use ontology to facilitate biology data mining, would it be better to create two ontologies (biology, and data mining) rather than one (universal framework of bioDataMining)? To what extent Instantiating the ontology to instances will benefit my framework? Or can I implement it without much instances (to write my thesis) I know this is a abstract question, still hope I can get some hints. Building ontology is really tough since you can build one in so many ways. If your domain is big enough or the domain can be deemed as several modules each of which has a distinct concentration , it should be better to split the domain into several small ontologies. It cause no harm since you can import any part as long as you wish to. However, it is really up to the ontology engineer, in this case it's you, to decide which is the better way. You'd better take a look at some ontological engineering books to get a feel about this project. As for the instantiation, it is still up to you. If your thesis are working on TBox only, then few or even no instance will be acceptable. Otherwise you may need to instantiate the classes on demand.

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